Children’s Health

The team, led from Great Ormond Street Hospital (GOSH), UCL Great Ormond Street Institute of Child Health (UCL GOS ICH) and the Istituto Zooprofilattico Sperimentale delle Venezie (Legnaro, Italy), have built on recent advances to grow ‘mini-organs’ in a laboratory, known as organoids. These organoids provide researchers with invaluable tools to study how organs function
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Vanderbilt Kennedy Center (VKC) researchers, as part of the Centers for Disease Control and Prevention (CDC) Autism and Developmental Disabilities Monitoring (ADDM) network, report an increase in the number of children in Tennessee with autism spectrum disorder (ASD). The researchers published their findings in the CDC’s Morbidity and Mortality Weekly Report series on Dec. 2.
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A bacterium common in the mouse gut microbiome can charge up the immune system to fight cancer cells in the colon, researchers from the University of Pittsburgh School of Medicine report today in the journal Immunity. The study showed that bacterium Helicobacter hepaticus boosted adaptive immune response and prompted selective activation of Helper T cells
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Many countries have implemented various nonpharmaceutical interventions (NPIs) such as social distancing mandates and lockdowns in response to the coronavirus disease 19 (COVID-19) pandemic. Although these measures reduced stress on the healthcare system in the absence of vaccines, they were associated with major socioeconomic costs. This led to a revival of the debate on whether
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In the first MRI-based study to investigate pre-natal alcohol exposure, researchers found significant changes in the brain structure of fetuses exposed to alcohol compared to healthy controls. Results of the study are being presented today at the annual meeting of the Radiological Society of North America (RSNA). Fetal alcohol syndrome is a worldwide problem in
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In pediatric and young adult patients with acute lymphoblastic leukemia (ALL) treated with tisagenlecleucel (Kymriah), DNA sequencing-based detection of residual disease between three and 12 months accurately identified all patients who would eventually relapse, while other methods were less predictive. Journal in Which the Study was Published: Blood Cancer Discovery, a journal of the American
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This first-in-human study of golodirsen showed its long-term safety and biologic activity in patients with Duchenne Muscular Dystrophy (DMD). The approved exon-skipping therapy is designed to enable the production of functional dystrophin proteins, as described in the peer-reviewed journal Nucleic Acid Therapeutics. Golodirsen was tested in ambulatory patients with exon 53 skip amenable DMD. They
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As the COVID-19 pandemic nears the two-year mark, Northwestern Medicine scientists continue to tackle every facet of the disease, from investigating coronavirus vaccines’ potential for providing immunity against similar coronaviruses to developing novel rapid antigen-based tests and examining disparities in COVID-19 case and mortality rates in Chicago. Coronavirus vaccines may provide cross-protective immunity Northwestern Medicine
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During the first 9 months of the COVID-19 pandemic, researchers did not find a significant difference in the number of new cancer diagnoses in Canadian children compared with before the pandemic, according to a study published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.210659. “Our findings suggest that among children in Canada, cancer diagnosis was not
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Saliva samples are easy to obtain and useful for measuring antibodies to SARS-CoV-2 in children, which could facilitate epidemiological surveillance in school settings. The study, a collaboration between the Barcelona Institute for Global Health (ISGlobal), an institution supported by “la Caixa” Foundation, and the Hospital Sant Joan de Déu (HSJD), followed over 1,500 children who
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When the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the virus responsible for the coronavirus disease 2019 (COVID-19), first spread across the globe, many governments were forced to enact costly and restrictive measures to reduce the transmission. These measures often consisted of mandatory mask-wearing, the closing of public spaces, and even full lockdowns/stay-at-home
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A team of UK-based scientists has recently evaluated the effectiveness of coronavirus disease 2019 (COVID-19) vaccines in preventing household transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in England. Their findings indicate that the vaccines effectively reduce transmission of SARS-CoV-2 alpha and delta variants from breakthrough infections in the household setting, despite having reduced
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Coronaviruses have caused three major epidemics since 2003, with the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic being the most concerning of them all. In all previous endemic cases, the emergence of coronaviruses among humans has been associated with zoonotic transmissions from animal reservoirs, proving the propensity of such pathogens to be transmitted
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Multisystem inflammatory syndrome (MIS) is a new systemic inflammatory acute onset disease that mainly affects children (MIS-C) and, at a lesser frequency, adults. The disease usually occurs in children 3-6 weeks after acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Study: Autoantibody Release in Children after Corona Virus mRNA Vaccination: A Risk Factor of
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